Wanli Liu Lab

An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment

2022

期刊 Journal of Clinical Investigation

作者 Bing Yang# · Zhen Zhang · Xiangjun Chen · Xu-Yan Wang · Shishang Qin · Liaoqi Du · Changjiang Yang · Liyu Zhu · Wenbo Sun · Yongjie Zhu · Qinwen Zheng · Shidong Zhao · Quan Wang · Long Zhao · Yilin Lin · Jinghe Huang · Fan Wu · Lu Lu · Fei Wang · Wenjie Zheng · Xiao-Hua Zhou · Xiaozhen Zhao · Ziye Wang · Sun Xiao-Lin · Yingjiang Ye · Shan Wang · Zhanguo Li · Hai Qi · Zemin Zhang · Dong-Ming Kuang · Lei Zhang · Zhanlong Shen · Wanli Liu*

Farnesyl pyrophosphate is a new danger signal inducing acute cell death

2021

期刊 PLOS Biology

作者 Jing Chen · Xiaochen Zhang · Liping Li · Xianqiang Ma · Chunxiao Yang · Zhaodi Liu · Chenyang Li · Maria J. Fernandez-Cabezudo · Basel K. Al-Ramadi · Chuan Wu · Weishan Huang · Yong Zhang · Yonghui Zhang · Wanli Liu*

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

2019

期刊 eLife

作者 Zhixun Shen · Sichen Liu · Xinxin Li · Zhengpeng Wan# · Youxiang Mao · Chunlai Chen · Wanli Liu*

Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function

2019

期刊 Science Advances

作者 Xingwang Zhao · Hengyi Xie · Meng Zhao · Asma Ahsan · Xinxin Li · Fei Wang · Junyang Yi · Zhiyong Yang · Chuan Wu · Indu Raman · Quan-Zhen Li · Tae Jin Kim · Wanli Liu*

Traction force-mediated B cell activation: how and why

2019

期刊 Science China Life Sciences

作者 Feng Lin · Junyi Wang · Yingyue Zeng · Chunyang Xiong · Wanli Liu*

An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation

2018

期刊 Science

作者 Xiangjun Chen · Xiaolin Sun · Wei Yang · Bing Yang# · Xiaozhen Zhao · Shuting Chen1 · Lili He · Hui Chen · Changmei Yang · Le Xiao · Zai Chang · Jianping Guo · Jing He · Fuping Zhang · Fang Zheng · Zhibin Hu · Zhiyong Yang · Jizhong Lou · Wenjie Zheng · Hai Qi · Chenqi Xu · Hong Zhang · Hongying Shan · Xu-Jie Zhou · Qingwen Wang · Yi Shi · Luhua Lai · Zhanguo Li · Wanli Liu*

MARCKS regulates tonic and chronic active B cell receptor signaling

2018

期刊 Leukemia

作者 Chenguang Xu · Yan Fang · Zhiyong Yang · Yukai Jing · Yonghui Zhang · Chaohong Liu · Wanli Liu*

PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

2018

期刊 The Journal of Cell Biology

作者 Zhengpeng Wan# · Chenguang Xu · Xiangjun Chen · Hengyi Xie · Zongyu Li# · Jing Wang · Xingyu Ji · Haodong Chen · Qinghua Ji · Samina Shaheen · Yang Xu · Fei Wang · Zhuo Tang · Ji-Shen Zheng · Wei Chen · Jizhong Lou · Wanli Liu*

Profiling the origin, dynamics, and function of traction force in B cell activation

2018

期刊 Science Signaling

作者 Junyi Wang · Feng Lin · Zhengpeng Wan# · Xiaolin Sun · Yun Lu · Jianyong Huang · Fei Wang · Yingyue Zeng · Ying-Hua Chen · Yan Shi · Wenjie Zheng · Zhanguo Li · Chunyang Xiong · Wanli Liu*

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses

2018

期刊 Frontiers in Immunology

作者 Jing Wang · Sichen Liu · Baidong Hou · Meixiang Yang · Zhongjun Dong · Hai Qi · Wanli Liu*

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

2018

期刊 Cell

作者 Yun Xia# · Yonghua Xie# · Zhengsen Yu# · Hongying Xiao · Guimei Jiang · Xiaoying Zhou · Yunyun Yang · Xin Li · Meng Zhao · Liping Li · Mingke Zheng · Shuai Han · Zhaoyun Zong · Xianbin Meng · Haiteng Deng · Huahu Ye · Yunzhi Fa · Haitao Wu · Eric Oldfield · Xiaoyu Hu · Wanli Liu* · Yan Shi · Yonghui Zhang · ...

A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

2017

期刊 Science Immunology

作者 Chenguang Xu · Hengyi Xie · Xingdong Guo · Haipeng Gong · Lei Liu · Hai Qi · Chenqi Xu · Wanli Liu*

Growth of B cell receptor microclusters is regulated by PIP2 and PIP3 equilibrium and Dock2 recruitment and activation

2017

期刊 Cell Reports

作者 Jing Wang · Liling Xu · Samina Shaheen · Sichen Liu · Wenjie Zheng · Xiaolin Sun · Zhanguo Li · Wanli Liu*

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232

2016

期刊 J Exp Med

作者 Liling Xu · Mengdie Xia# · Jun Guo · Xiaolin Sun · Hua Li · Chenguang Xu · Xiaomei Gu · Haowen Zhang · Junyang Yi · Yan Fang · Hengyi Xie · Jing Wang · Zhixun Shen · Boxin Xue · Yujie Sun · Tobias Meckel · Ying-Hua Chen · Zhibin Hu · Zhanguo Li · Chenqi Xu · Haipeng Gong · Wanli Liu*

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

2015

期刊 Nature Communications

作者 Xiangjun Chen · Weiling Pan · Yinqiang Sui · Hua Li · Xiaoshan Shi · Xingdong Guo · Hai Qi · Chenqi Xu · Wanli Liu*

A negative-feedback function of PKCβ in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse

2015

期刊 J Leukoc Biol

作者 Ce Liu · Xingwang Zhao · Liling Xu · Junyang Yi · Samina Shaheen · Weidong Han · Fei Wang · Wenjie Zheng · Chenqi Xu · Wanli Liu*

Substrate stiffness regulates B-cell activation, proliferation, class switch and T-cell-independent antibody responses in vivo

2015

期刊 Eur J Immunol

作者 Yingyue Zeng · Junyang Yi · Zhengpeng Wan# · Kai Liu · Ping Song · Alicia Chau · Fei Wang · Zai Chang · Weidong Han · Wenjie Zheng · Ying-Hua Chen · Chunyang Xiong · Wanli Liu*

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

2015

期刊 eLife

作者 Zhengpeng Wan# · Xiangjun Chen · Haodong Chen · Qinghua Ji · Yingjia Chen · Jing Wang · Yiyun Cao · Fei Wang · Jizhong Lou · Zhuo Tang · Wanli Liu*

The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules

2015

期刊 J Leukoc Biol

作者 Liling Xu · Arturs Auzins · Xiaolin Sun · Yinsheng Xu · Fiona Harnischfeger · Yun Lu · Juan Qiao · Zhanguo Li · Ying-Hua Chen · Wenjie Zheng · Wanli Liu*

No receptor stands alone: IgG B cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

2014

期刊 Cell Research

作者 Yinsheng Xu · Meng Zhao · Yilin Fan · Susan K. Pierce* And Wanli Liu*

Through an ITIM-independent mechanism the FcgRIIB blocks B cell activation by disrupting the colocalized microclustering of the BCR and CD19

2014

期刊 J Immunol

作者 Liling Xu · Gen Li · Jing Wang · Yilin Fan · Zhengpeng Wan# · Shaosen Zhang · Samina Shaheen · Jing Li · Li Wang · Cai Yue · Yan Zhao · Fei Wang · Joseph Brzostowski · Yinghua Chen* · Wenjie Zheng · Wanli Liu*

A new and robust method of tethering IgG surrogate antigens on lipid bilayer membranes to facilitate the TIRFM based live cell and single molecule imaging experiments

2013

期刊 Plos One

作者 Shaosen Zhang · Liling Xu · Xingwang Zhao · Xin Chen · Zhengpeng Wan# · Yinsheng Xu · Wanli Liu*

B cell activation is regulated by the stiffness properties of the substrate presenting the antigens

2013

期刊 J Immunol

作者 Zhengpeng Wan# · Shaosen Zhang · Yilin Fan · Kai Liu · Feng Du · Angel M. Davey · Huiyuan Zhang · Weidong Han · Chunyang Xiong · Wanli Liu*

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features

2012

期刊 Protein & Cell

作者 Zhengpeng Wan# · Wanli Liu*

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An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment

Farnesyl pyrophosphate is a new danger signal inducing acute cell death

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function

Traction force-mediated B cell activation: how and why

An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation

MARCKS regulates tonic and chronic active B cell receptor signaling

PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

Profiling the origin, dynamics, and function of traction force in B cell activation

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

Growth of B cell receptor microclusters is regulated by PIP2 and PIP3 equilibrium and Dock2 recruitment and activation

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

A negative-feedback function of PKCβ in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse

Substrate stiffness regulates B-cell activation, proliferation, class switch and T-cell-independent antibody responses in vivo

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules

No receptor stands alone: IgG B cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

Through an ITIM-independent mechanism the FcgRIIB blocks B cell activation by disrupting the colocalized microclustering of the BCR and CD19

A new and robust method of tethering IgG surrogate antigens on lipid bilayer membranes to facilitate the TIRFM based live cell and single molecule imaging experiments

B cell activation is regulated by the stiffness properties of the substrate presenting the antigens

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features