研究方向

1. 干细胞命运调控：皮肤及其附属器（毛囊、触觉穹窿）发育机制，尤其专注触觉感受器默克尔细胞发育和调控。
2. 皮肤及其附属器形态、结构和功能异常所致疾病病理研究。

PI简介

肖瑛博士本科毕业于中国科学技术大学，在中科院上海药物所获得博士学位，随后赴美国国立卫生研究院（NIH）进行博士后训练并工作，2018年9月入职浙江大学医学院附属邵逸夫医院，任独立课题组组长特聘研究员。主要从事干细胞命运决定机制研究，在皮肤及其附属器发育、皮肤干细胞调控机制领域取得了重要成果，其中包括毛囊干细胞的血管微环境，皮肤触觉感受器的干细胞微环境调控机制以及发育机制。已在PNAS、Plos Genetics、JID等国际一流专业杂志发表27篇SCI论文，这些论文被引用800余次，其中2篇被F1000推荐并高度评价。回国3年已获得3项国家级基金，包括2项国自然基金和1项科技部重大专项“干细胞研究与器官修复”（课题负责人）资助。浙大教师主页：https://person.zju.edu.cn/XYlab ，邵逸夫医院网页：zp.srrsh.com/index/index/announcement_desc/id/56.html

发表文章

主要论文

1. 芮晨，袁绘普，张雅君，陈晶，王超尘，肖瑛. 《默克尔细胞的发育研究进展》, 中国细胞生物学学报. ( 2021)

2. Chachar S*, Chen J*, Qin YM, Wu X, Yu HY, Zhou Q, Fan XJ, Wang CC, Isaac Brownell I, Xiao Y^#. Reciprocal signals between nerve and epithelium: How do neurons talk with epithelial cells? American Journal of Stem Cells. (2021)

3. Shi L*, Ding R*, Zhang TT*, Wu W*, Wang ZY, Jia XZ, Li KN, Liang Y, Li J, Zhu MY, Huang B, Wu LX, Wu M, Chen J, Wang CC, Huang B, Liu CD, Shen HB, Wang QH, Xia XY^#, Li PP^#, Lyu SL^#, Xiao Y^#. Comparative characterization and risk stratification of asymptomatic and presymptomatic patients with COVID-19. Frontiers in immunology. (2021)

4. Zheng L, Rui C, Zhang H, Chen J, Jia XZ^#, Xiao Y^#. Sonic hedgehog signaling in epithelial tissue development. Regenerative Medicine Research 7:3. (2019)

5. Jia XZ, Cheng H^#, Xiao Y^#. Unfolding the Pathogenesis of Systemic Sclerosis through Epigenomics. STEMedicine. (2019)

6. Jia XZ*, Lu MJ*, Rui C, Xiao Y^#. Consensus expressed CXCL8 and MMP9 identified by meta-analyzed perineural invasion gene signature in gastric cancer microarray data. Frontiers in Genetics. 10: 851. (2019)

7. Xiao Y, Thoresen D, Miao L, Williams J, Wang C, Atit R, Wong S, Brownell I. A cascade of Wnt, Eda, and Shh signaling is essential for touch dome Merkel cell development. PLOS Genetics. 12(7): e1006150. (2016)

8. Xiao Y, Thoresen D, Williams J, Wang C, Perna J, Petrova R, Brownell I. Neural hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium. Proc Natl Acad Sci USA. 112(23):7195-200. (2015)

9. Xiao Y, Williams J, Brownell I. Merkel cells and touch domes: More than mechanosensory functions. Experimental Dermatology 23(10):692-5. (2014)

10. Xiao Y, Woo WM, Nagao K, Li WL, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I. Perivascular hair follicle stem cells associate with a venule annulus. Journal of Investigative Dermatology. 133(10):2324-31. (2013) Recognized by F1000Prime: https://f1000.com/prime/717997121

11. Xiao Y*, Xue X*, Wu XF, Xin GZ, Qian Y, Xie TP, Gong LK, Ren J. Betanaphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacologica Sinica. 30(11): 15591565. (*Equal contribution) (2009)

12. Xiao Y, Ge M, Xue X, Wang CC, Wang H, Wu XF, Li L, Liu LL, Qi XM, Zhang YH, Li Y, Luo H, Xie TP, Gu J, Ren J. Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney International. 73(11): 1231-9. (2008)  Recognized by F1000Prime:  http://f1000.com/prime/1115386 

13. Xue X*, Xiao Y*, Zhu HL, Wang H, Liu YZ, Xie TP, Ren J. Induction of P450 1A by 3-Methylcholanthrene Protects Mice from Aristolochic Acid I-Induced Acute Renal Injury. Nephrology Dialysis Transplantation. 23(10):3074-81. (* Equal contribution) (2008)

合作论文

14. Zhang H, Fu XQ, Ao Y, Nan MM, Qiu ZY, Jia XZ, Xiao Y, Liu DJ, Guo XD. ANXA1 affects murine hair follicle growth through EGF signaling pathway. Gene. 771:145343. (2020)

15. Gaiser MR, Weis CA, Gaiser T, Jiang H, Buder-bakhaya K, Herpel, Warth A, Xiao Y, Miao L, Brownell I. Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells. OncoImmunology. 7(5):e1426517. (2018)

16. Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci USA. 109(38):15324-9. (2012)

17. Liu X, Xue X, Gong L, Qi X, Wu Y, Xing G, Luan Y, Xiao Y, Wu X, Li Y, Chen M, Miao LL, Yao J, Gu J, Lin DH, Ren J. ¹H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice. Metabolomics. 8(5):907-918. (2012)

18. Xue X, Gong LK, Qi XM, Xing GZ, Yao J, Luan Y, Xiao Y, Li Y, Wu XF, Chen M, Gu J, Ren J. Knockout of hepatic P450 reductase aggravates triptolide-inducedtoxicity. Toxicology Letters. 205(1):47-54. (2011)

19. Chen M, Gong LK, Qi XM, Xing GZ, Luan Y, Wu YF, Xiao Y, Xue X, Pan GY, Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicology Science. 122(2):288-96. (2011)