胃癌基础与临床转化研究实验室

作者 Sukesh Voruganti · Fangxiu Xu · Jiang-Jiang Qin · Yan Guo · Sushanta Sarkar · Ming Gao · Zhijie Zheng · Ming-Hai Wang · Jianwei Zhou · Biyun Qian · Ruiwen Zhang · Wei Wang

A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study

2014

期刊 Journal of Chromatography B

作者 Subhasree Nag · Jiang-Jiang Qin · Shivaputra Patil · Hemantkumar Deokar · John K Buolamwini · Wei Wang · Ruiwen Zhang

ChemInform Abstract: Selective Cytotoxicity, Inhibition of Cell Cycle Progression, and Induction of Apoptosis in Human Breast Cancer Cells by Sesquiterpenoids from Inula lineariifolia Turcz.

2014

期刊 ChemInform

作者 Wei-Dong Zhang · Et Al. Et Al.

Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice

2014

期刊 Biomedical Chromatography

作者 Subhasree Nag · Jiang-Jiang Qin · Sukesh Voruganti · Ming-Hai Wang · Horrick Sharma · Shivaputra Patil · John K Buolamwini · Wei Wang · Ruiwen Zhang

Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

2014

期刊 Gastroenterology

作者 Wei Wang · Jiang-Jiang Qin · Sukesh Voruganti · Ming-Hai Wang · Horrick Sharma · Shivaputra Patil · Jianwei Zhou · Hui Wang · Debabrata Mukhopadhyay · John K Buolamwini · Ruiwen Zhang

Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation

2014

期刊 Oncotarget

作者 Jiang-Jiang Qin · Wei Wang · Sukesh Voruganti · Hui Wang · Wei-Dong Zhang · Ruiwen Zhang

Inulasesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity

2014

期刊 Expert Opinion on Investigational Drugs

作者 Guo-Wei Wang · Jiang-Jiang Qin · Xiang-Rong Cheng · Yun-Heng Shen · Lei Shan · Hui-Zi Jin · Wei-Dong Zhang

NFAT as cancer target: Mission possible?

2014

期刊 Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

作者 Jiang-Jiang Qin · Subhasree Nag · Wei Wang · Jianwei Zhou · Wei-Dong Zhang · Hui Wang · Ruiwen Zhang

RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo

2014

期刊 Oncotarget

作者 Wei Wang · Jianwen Cheng · Jiang-Jiang Qin · Sukesh Voruganti · Subhasree Nag · Jia Fan · Qiang Gao · Ruiwen Zhang

The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models

2014

期刊 Nature Communications

作者 Wei Wang · Jiang-Jiang Qin · Sukesh Voruganti · Kalkunte S. Srivenugopal · Subhasree Nag · Shivaputra Patil · Horrick Sharma · Ming-Hai Wang · Hui Wang · John K Buolamwini · Ruiwen Zhang

Aphanamgrandiol A, a new triterpenoid with a unique carbon skeleton from Aphanamixis grandifolia

2013

期刊 Fitoterapia

作者 Qi Zeng · Bin Guan · Jie Ren · Chun-Hui Wang · Xiang-Rong Cheng · Jiang-Jiang Qin · Shi-Kai Yan · Hui-Zi Jin · Wei-Dong Zhang

Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.

2013

期刊 Phytochemistry

作者 Xiang-Rong Cheng · Shou-De Zhang · Chun-Hui Wang · Jie Ren · Jiang-Jiang Qin · Xue Tang · Yun-Heng Shen · Shi-Kai Yan · Hui-Zi Jin · Wei-Dong Zhang

Chemical Constituents from Aphanamixis grandifolia

2013

期刊 Chemistry of Natural Compounds

作者 Qi Zeng · Ji Ye · Jie Ren · Xiang-Rong Cheng · Jiang-Jiang Qin · Hui-Zi Jin · Wei-Dong Zhang

Chemical constiuents of Euonymus acanthocarpus

2013

期刊 Chemistry of Natural Compounds

作者 Jia-Xian Zhu · Jiang-Jiang Qin · Fei Zhang · Rui-Jie Chang · Jie Ren · Xiang-Rong Cheng · Qi Zeng · Hui-Zi Jin · Wei-Dong Zhang

Five new sesquiterpene lactones from Inula hupehensis

2013

期刊 Archives of Pharmacal Research

作者 Jie Ren · Jiang-Jiang Qin · Xiang-Rong Cheng · Shi-Kai Yan · Hui-Zi Jin · Wei-Dong Zhang

Hookerolides A–D, the first naturally occurring C17-pseudoguaianolides from Inula hookeri

2013

期刊 Tetrahedron Letters

作者 Xiang-Rong Cheng · Jie Ren · Chun-Hui Wang · Bin Guan · Jiang-Jiang Qin · Shi-Kai Yan · Hui-Zi Jin · Wei-Dong Zhang

Identification and structural characterization of dimeric sesquiterpene lactones inInula japonicaThunb. by high-performance liquid chromatography/electrospray ionization with multi-stage mass spectrometry

2013

期刊 Rapid Communications in Mass Spectrometry

作者 Ji Ye · Jiang-Jiang Qin · Juan Su · Shan Lin · Ying Huang · Hui-Zi Jin · Wei-Dong Zhang

Identification of the ZAK-MKK4-JNK-TGFβ Signaling Pathway as a Molecular Target for Novel Synthetic Iminoquinone Anticancer Compound BA-TPQ

2013

期刊 Current Cancer Drug Targets

作者 Deng Chen · Wei Wang · Jiang-Jiang Qin · Ming-Hai Wang · Srinivasan Murugesan · Dwayaja Nadkarni · Sadanandan Velu · Hui Wang · Ruiwen Zhang

Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF- B

2013

期刊 Clinical Cancer Research

作者 X. Li · X. Yang · Y. Liu · N. Gong · W. Yao · P. Chen · J. Qin · H. Jin · J. Li · R. Chu · L. Shan · R. Zhang · W. Zhang · H. Wang

Japonicones Q–T, four new dimeric sesquiterpene lactones from Inula japonica Thunb.

2013

期刊 Fitoterapia

作者 Jia-Xian Zhu · Jiang-Jiang Qin · Hui-Zi Jin · Wei-Dong Zhang

miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents

2013

期刊 Current Cancer Drug Targets

作者 Biyun Qian · Subhasree Nag · Yuliang Su · Sukesh Voruganti · Jiang-Jiang Qin · Ruiwen Zhang · William Cho

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Oral delivery of anti-MDM2 inhibitor SP141-loaded FcRn-targeted nanoparticles to treat breast cancer and metastasis

Abstract 2433: A novel MDM2 inhibitor suppresses breast cancer growth and metastasis

Abstract 2434: The anticancer activity of Japonicone A is mediated by inhibiting NFAT1-MDM2 pathway

Abstract 5266: RYBP expression predicts survival of patients with hepatocellular carcinoma, and regulates response to chemotherapy

Abstract C93: RYBP predicts survival of patients with non-small cell lung cancer and sensitizes chemotherapy

Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats

Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapA

Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

RYBP predicts survival of patients with non-small cell lung cancer and regulates tumor cell growth and the response to chemotherapy

A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study

ChemInform Abstract: Selective Cytotoxicity, Inhibition of Cell Cycle Progression, and Induction of Apoptosis in Human Breast Cancer Cells by Sesquiterpenoids from Inula lineariifolia Turcz.

Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice

Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation

Inulasesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity

NFAT as cancer target: Mission possible?

RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo

The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models

Aphanamgrandiol A, a new triterpenoid with a unique carbon skeleton from Aphanamixis grandifolia

Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.

Chemical Constituents from Aphanamixis grandifolia

Chemical constiuents of Euonymus acanthocarpus

Five new sesquiterpene lactones from Inula hupehensis

Hookerolides A–D, the first naturally occurring C17-pseudoguaianolides from Inula hookeri

Identification and structural characterization of dimeric sesquiterpene lactones inInula japonicaThunb. by high-performance liquid chromatography/electrospray ionization with multi-stage mass spectrometry

Identification of the ZAK-MKK4-JNK-TGFβ Signaling Pathway as a Molecular Target for Novel Synthetic Iminoquinone Anticancer Compound BA-TPQ

Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF- B

Japonicones Q–T, four new dimeric sesquiterpene lactones from Inula japonica Thunb.

miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents