胃癌基础与临床转化研究实验室

Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

2020

期刊 Frontiers in Pharmacology

作者 Xiaofang Luo · Qiu-Xu Teng · Jin-Yun Dong · Dong-Hua Yang · Meifeng Wang · Wubliker Dessie · Jiang-Jiang Qin · Zi-Ning Lei · Jing-Quan Wang · Zuodong Qin · Zhe-Sheng Chen

Aspeterreurone A, a Cytotoxic Dihydrobenzofuran–Phenyl Acrylate Hybrid from the Deep-Sea-Derived Fungus Aspergillus terreus CC-S06-18

2020

期刊 Journal of Natural Products

作者 Weiyi Wang · Jing Yang · Yan-Yan Liao · Gang Cheng · Jing Chen · Shaowei Mo · Li Yuan · Xiang-Dong Cheng · Jiang-Jiang Qin · Zongze Shao

Chemical constituents from wetland soil fungus Penicillium oxalicum GY1

2020

期刊 Fitoterapia

作者 Ting Ding · Yuan Zhou · Jiang-Jiang Qin · Luo-Jie Yang · Wei-Dong Zhang · Yun-Heng Shen

Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

2020

期刊 Journal of Natural Products

作者 Weiyi Wang · Jing Yang · Yan-Yan Liao · Gang Cheng · Jing Chen · Xiang-Dong Cheng · Jiang-Jiang Qin · Zongze Shao

Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Pathways Associated With Clinical Outcome in Hepatocellular Carcinoma

2020

期刊 Frontiers in Genetics

作者 Yubin Li · Runzhe Chen · Jian Yang · Shaowei Mo · Kelly Quek · Chung H. Kok · Xiang-Dong Cheng · Saisai Tian · Weidong Zhang · Jiang-Jiang Qin

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

2020

期刊 Molecular Cancer

作者 Li Yuan · Zhi-Yuan Xu · Shan-Ming Ruan · Shaowei Mo · Jiang-Jiang Qin · Xiang-Dong Cheng

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

2020

期刊 Drug Resistance Updates

作者 Jinyun Dong · Zuodong Qin · Wei-Dong Zhang · Gang Cheng · Assaraf G. Yehuda · Charles R. Ashby · Zhe-Sheng Chen · Xiang-Dong Cheng · Jiang-Jiang Qin

Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges

2020

期刊 Frontiers in Oncology

作者 De-Hua Yu · Zhi-Yuan Xu · Shaowei Mo · Li Yuan · Xiang-Dong Cheng · Jiang-Jiang Qin

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

2020

期刊 Frontiers in Cell and Developmental Biology

作者 Si-Min Qi · Gang Cheng · Xiang-Dong Cheng · Zhiyuan Xu · Beihua Xu · Wei-Dong Zhang · Jiang-Jiang Qin

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

2020

期刊 Frontiers in Pharmacology

作者 Wen-Kai Yu · Zhi-Yuan Xu · Li Yuan · Shaowei Mo · Beihua Xu · Xiang-Dong Cheng · Jiang-Jiang Qin

Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice

2020

期刊 Frontiers in Pharmacology

作者 Jia Zhang · Weiyi Wang · Yuan Zhou · Jing Yang · Jingli Xu · Zhiyuan Xu · Beihua Xu · Li Yan · Xiang-Dong Cheng · Minghua Li · Jiang-Jiang Qin

Abstract 3858: Inflammation and oncogene in hepatocellular carcinoma: Clinical relevance and experimental targeted therapy

2019

会议 Experimental and Molecular Therapeutics

作者 Wei Wang · Jianwen Cheng · Jiang-Jiang Qin · Bo Hu · Bhavitavya Nijampatnam · Sadanandan Velu · Xin-Rong Yang · Jia Fan · Ruiwen Zhang

A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

2019

期刊 Genes & Diseases

作者 Wei Wang · Bo Hu · Jiang-Jiang Qin · Jian-Wen Cheng · Xin Li · Mehrdad Rajaei · Jia Fan · Xin-Rong Yang · Ruiwen Zhang

Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review

2019

期刊 Cell Communication and Signaling

作者 Jiang-Jiang Qin · Xiang-Dong Cheng · Jia Zhang · Wei-Dong Zhang

Is CDK9 a promising target for both primary and metastatic osteosarcoma?

2019

期刊 EBioMedicine

作者 Jiang-Jiang Qin

MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53

2019

期刊 Cancer Letters

作者 Wei Wang · Jian-Wen Cheng · Jiang-Jiang Qin · Bo Hu · Xin Li · Bhavitavya Nijampatnam · Sadanandan E. Velu · Jia Fan · Xin-Rong Yang · Ruiwen Zhang

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

2019

期刊 Journal of Experimental & Clinical Cancer Research

作者 Jiang-Jiang Qin · Li Yan · Jia Zhang · Wei-Dong Zhang

Targeting MDM2 for novel molecular therapy: Beyond oncology

2019

期刊 Medicinal Research Reviews

作者 Wei Wang · Jiang-Jiang Qin · Mehrdad Rajaei · Xin Li · Xiaoyi Yu · Courtney Hunt · Ruiwen Zhang

Abstract 4863: Targeting the NFAT1-MDM2-MDMX network for prostate cancer therapy

2018

会议 Experimental and Molecular Therapeutics

作者 Jiang-Jiang Qin · Xin Li · Wei Wang · Ruiwen Zhang

Abstract 4867: Treating hepatocellular carcinoma metastasis and overcoming chemoresistance through inhibiting the MDM2 oncogene

2018

会议 Experimental and Molecular Therapeutics

作者 Wei Wang · Bo Hu · Jiang-Jiang Qin · Jianwen Cheng · Xin Li · Ming Hu · John Buolamwini · Xin-Rong Yang · Jia Fan · Ruiwen Zhang

Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy

2018

期刊 Cancer Research

作者 Wei Wang · Jiang-Jiang Qin · Sukesh Voruganti · Bhavitavya Nijampatnam · Sadanandan E. Velu · Ke-He Ruan · Ming Hu · Jianwei Zhou · Ruiwen Zhang

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

2018

期刊 Frontiers in Pharmacology

作者 Jiang-Jiang Qin · Wei Wang · Xin Li · Hemantkumar Deokar · John K Buolamwini · Ruiwen Zhang

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

2018

期刊 Genes & Diseases

作者 Jiang-Jiang Qin · Xin Li · Courtney Hunt · Wei Wang · Hui Wang · Ruiwen Zhang

Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms

2018

期刊 Carcinogenesis

作者 Wei Wang · Jiang-Jiang Qin · Xin Li · Guanyu Tao · Qiang Wang · Xuming Wu · Jianwei Zhou · Xiaolin Zi · Ruiwen Zhang

Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1–MDM2–p53 Pathway

2017

书籍 Progress in Molecular Biology and Translational Science

作者 Jiang-Jiang Qin · Wei Wang · Ruiwen Zhang

Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes

2017

期刊 Acta Biomaterialia

作者 Bing Xue · Wei Wang · Jiang-Jiang Qin · Bhavitavya Nijampatnam · Srinivasan Murugesan · Veronika Kozlovskaya · Ruiwen Zhang · Sadanandan E. Velu · Eugenia Kharlampieva

Novel natural product therapeutics targeting both inflammation and cancer

2017

期刊 Chinese Journal of Natural Medicines

作者 Jiangjiang Qin · Wei Wang · Ruiwen Zhang

Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen

2017

期刊 Frontiers in Pharmacology

作者 Jiang-Jiang Qin · Xin Li · Wei Wang · Xiaolin Zi · Ruiwen Zhang

Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy

2016

期刊 Journal of Biomedical Research

Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy

2016

期刊 Oncotarget

作者 Jiang-Jiang Qin · Wei Wang · Sushanta Sarkar · Sukesh Voruganti · Rajesh Agarwal · Ruiwen Zhang

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Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

Aspeterreurone A, a Cytotoxic Dihydrobenzofuran–Phenyl Acrylate Hybrid from the Deep-Sea-Derived Fungus Aspergillus terreus CC-S06-18

Chemical constituents from wetland soil fungus Penicillium oxalicum GY1

Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Pathways Associated With Clinical Outcome in Hepatocellular Carcinoma

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Targeting β-Catenin Signaling by Natural Products for Cancer Prevention and Therapy

Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice

Abstract 3858: Inflammation and oncogene in hepatocellular carcinoma: Clinical relevance and experimental targeted therapy

A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review

Is CDK9 a promising target for both primary and metastatic osteosarcoma?

MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

Targeting MDM2 for novel molecular therapy: Beyond oncology

Abstract 4863: Targeting the NFAT1-MDM2-MDMX network for prostate cancer therapy

Abstract 4867: Treating hepatocellular carcinoma metastasis and overcoming chemoresistance through inhibiting the MDM2 oncogene

Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms

Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1–MDM2–p53 Pathway

Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes

Novel natural product therapeutics targeting both inflammation and cancer

Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen

Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy

Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy