array(2) { ["lab"]=> string(4) "1419" ["publication"]=> string(5) "13313" } The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases - 赵斌课题组-免疫代谢 | LabXing

赵斌课题组-免疫代谢

简介 中南大学 湘雅二医院 糖尿病免疫学教育部重点实验室 国家代谢性疾病临床研究中心

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The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases

2021
期刊 Frontiers in Cell and Developmental Biology
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Over the past several decades, RNA modifications have rapidly emerged as an indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation at the sixth position of an adenine base in an RNA molecule, is the most prevalent RNA modification in both coding and noncoding RNAs. m6A has emerged as a crucial posttranscriptional regulator involved in both physiological and pathological processes. Based on accumulating evidence, m6A participates in the pathogenesis of immune-related diseases by regulating both innate and adaptive immune cells through various mechanisms. Autoimmune diseases are caused by a self-destructive immune response in the setting of genetic and environmental factors, and recent studies have discovered that m6A may play an essential role in the development of autoimmune diseases. In this review, we focus on the important role of m6A modification in biological functions and highlight its contributions to immune cells and the development of autoimmune diseases, thereby providing promising epitranscriptomic targets for preventing and treating autoimmune disorders.